Invisalign® clear aligners for kids: benefits and why starting early is important

As a parent, you want the best for your child, and that includes a healthy, confident smile. If you're wondering when to start thinking about your child's orthodontic care, you're not alone. Early evaluation and treatment can make a significant difference in their oral health journey.

Key Summary: Invisalign clear aligners for kids

  • Treatment can start as early as age six

  • Helps guide jaw growth and prevent complex issues in the future

  • Removable for easier eating and oral hygiene

  • More comfortable than traditional braces

  • Supports confidence and social comfort

Invisalign clear aligners for kids are a comfortable, removable orthodontic treatment option for children as young as six. Early treatment can guide jaw growth and correct bite issues, and reduce the need for more costly or invasive treatments, all while supporting your child's confidence and oral health.1

Why is early orthodontic evaluation important?

Quick answer: The American Association of Orthodontists recommends a first evaluation by age seven.1 Early assessment lets orthodontists identify bite problems, crowding, and jaw development issues while kids' bones are still growing, making treatment simpler, shorter, and more effective than waiting until all permanent teeth have come in.

Early orthodontic care can also prevent complex issues and lead to more cost-effective treatment in the long run.1 By identifying potential problems early, orthodontists can guide jaw growth, lower the risk of trauma to protruded front teeth, correct harmful oral habits, and improve appearance.

How common are orthodontic issues in children?

Orthodontic problems are far more prevalent in children than many parents realize. A 2024 systematic review published in Healthcare found that malocclusion, the clinical term for misaligned teeth or an incorrect bite, affects approximately 54% of preschool-age children worldwide.2 These conditions include crowding, spacing issues, crossbites, overbites, and underbites, and they often worsen with age if left untreated. Research shows that the best time to fix an overbite (a Class II malocclusion) is early on, ideally when a child is between seven and ten years old and still has a mix of baby and adult teeth. Starting treatment during this window gives much better results right away. In fact, early treatment corrects the alignment of back teeth by an average of 4.5 mm, compared to just 3.1 mm if you wait until their teenage years.3 The encouraging news for parents is that catching these issues early, when a child's jaw is still growing and more responsive to guidance, means treatment is typically less complex, less invasive, and more effective overall.

Misaligned teeth can affect a child way beyond just their smile, it can take a real toll on how they feel every day. Research shows that older kids (ages 11–14) with severe alignment issues score significantly lower in social well-being, meaning their confidence and friendships suffer the most.4 Another study found that younger kids (ages 8–10) with straight or only mildly misaligned teeth were 56% less likely to experience these negative impacts on their daily lives.5 Addressing these issues early with Invisalign clear aligners can help your child skip these struggles and grow up with a confident, happy smile.

What are the benefits of Invisalign clear aligners for kids?

Quick answer:

Invisalign clear aligners offer a modern, comfortable, and virtually invisible way to shape your child’s smile. Because they are removable, kids can enjoy all their favorite foods while easily brushing and flossing to maintain excellent oral hygiene. This seamless daily routine is backed by real clinic benefits: compared to traditional braces, Invisalign patients experience less pain, require nearly 80% fewer emergency appointments,6 and an average of 30% fewer routine doctor visits.7

Whether your child needs early intervention or your teen is ready for a full smile transformation, this proven system is designed to effectively correct everything from minor crowding to complex bite issues.8 In fact, over 6.4 million complex cases have already been successfully treated.9 In the hands of an experienced doctor, Invisalign clear aligners deliver a highly effective orthodontic experience with less pain and maximum comfort, keeping your child's life moving forward without interruption.10,11

What orthodontic conditions can Invisalign clear aligners treat?

Not all clear aligners are created equal. When it comes to fixing a wide variety of smile and bite issues, 94% of orthodontists agree that the Invisalign system makes it easy to customize treatment for teenagers.12 Whether your child has severe crowding, gaps, or a complex bite, an experienced provider has the tools to tailor a plan specifically for their growing smile.

In fact, for children dealing with a classic overbite, Invisalign clear aligners are clinically proven to correct the issue while gently guiding the lower jaw forward as they grow.13 The best part? It fixes the overbite without the need for bulky, separate metal appliances—which is exactly why 7 out of 10 parents prefer this streamlined approach over traditional alternatives.14

What technology is behind Invisalign clear aligners?

SmartTrack™ material is designed exclusively for the Invisalign system to optimally deliver the desired force systems to move teeth more predictably.15 Every aligner in the Invisalign treatment line is crafted from this clinically proven proprietary material, particularly valuable for growing patients, ensuring that each stage of treatment delivers precisely calibrated, consistent tooth movement as their smiles develop.

Are Invisalign clear aligners comfortable for kids?

Quick answer: Yes. Invisalign clear aligners are made from smooth, flexible material with no metal brackets or wires to irritate the mouth. Teens say Invisalign clear aligners cause less pain and discomfort than metal braces,16 and the removable design means no discomfort during meals or sports.

Don't let pain and discomfort slow them down. Invisalign clear aligners are a better experience than braces.16

Do Invisalign clear aligners help with oral hygiene?

Quick answer: Yes. Because Invisalign clear aligners are removable, children can brush and floss normally without navigating metal brackets or wires. Clinical studies show that kids using clear aligners have significantly less plaque buildup and healthier gums during treatment compared to those in fixed braces.17

Maintaining good oral hygiene is crucial during orthodontic treatment. During 12 months of orthodontic therapy, teenagers treated with Invisalign clear aligners demonstrate better compliance with oral hygiene and present less plaque and gingival inflammatory reactions than their peers with fixed appliances.17

The oral hygiene advantage of clear aligners isn’t just a theory, it’s consistently proven by clinical research. Independent reviews of patients show that those using clear aligners have significantly better gum health and less plaque buildup compared to those wearing traditional braces.18 Across multiple evaluations, aligner patients experienced healthier gums with less swelling, less bleeding, and less gum recession.19

In fact, a recent study focusing specifically on growing kids and teens found that clear aligners caused no increase in plaque buildup over a full year, noting that kids actually stepped up their at-home brushing routines while tracking their progress.19 Because Invisalign clear aligners are completely removable, children can brush and floss normally. This eliminates the tricky traps created by traditional metal brackets and wires, removing a major barrier to keeping their mouth healthy and clean.

Can orthodontic treatment support my child's breathing and sleep quality?

Quick answer: Potentially, yes. A narrow upper jaw can restrict the nasal airway and promote mouth breathing, snoring, and poor sleep. Early palatal expansion, available as part of Invisalign treatment, widens the jaw and nasal cavity, which research shows may reduce sleep-disordered breathing and improve airflow in children with narrow arches.

Many parents are surprised to learn that how a child's jaw grows is closely connected to how well they breathe. When a child has a narrow upper jaw, it restricts the nasal airway directly above it. This often forces them to breathe through their mouth, snore, and experience restless, disrupted sleep.

Fortunately, expanding the jaw early on can make a massive difference. Recent medical studies show that widening a narrow jaw significantly improves airflow and reduces sleep disruptions in children dealing with sleep apnea.20 One 2025 study found that nearly 80% of children who used a non-permanent jaw expansion device showed measurable improvements in their breathing and sleep quality.21

If your child regularly breathes through their mouth, snores at night, or wakes up feeling tired, it could be a sign of a narrow jaw. Ask your orthodontist if Invisalign palatal expansion is the right step to help them breathe easier and sleep better.

Does Invisalign treatment fit into my child's active lifestyle?

Because Invisalign clear aligners are completely removable, children can simply take them out whenever they eat—meaning absolutely no food restrictions and no banned snacks. They can also pop them out for sports or music practice and put them right back in when they're done, completely avoiding the uncomfortable scratches or broken wires that often come with traditional braces. 84% of prospective teen patients prefer Invisalign clear aligners over traditional metal braces.22

This flexibility makes a massive difference in a child's everyday happiness. In a global survey, 92% of orthodontists agreed that children who start early with Invisalign clear aligners enjoy a better quality of life compared to those using traditional, bulky appliances.23 Furthermore, a recent 2024 study confirmed that kids who are still losing baby teeth are much happier to wear their Invisalign aligners and find them significantly more comfortable during daily activities than old-school, removable plastic devices.24

Can Invisalign clear aligners support my child's confidence and wellbeing?

Adolescence is a formative period when self-image and peer relationships carry enormous weight. Children and teens with misaligned teeth often experience heightened self-consciousness, social anxiety, and emotional stress, all of which can affect their confidence at a pivotal time in their development. According to the American Association of Orthodontists, children and teens with significant dental misalignment often experience low self-esteem and increased social anxiety, and numerous studies confirm that patients report increased confidence, improved self-image, and more positive social interactions following orthodontic treatment.25

The discreet design of Invisalign clear aligners makes them especially well-suited for appearance-conscious children and teens. Unlike metal braces, Invisalign clear aligners are nearly invisible when worn, allowing kids to smile, speak, and engage socially throughout treatment without feeling self-conscious about their appearance. This is more than a cosmetic benefit: when children feel good about how they look during treatment, they are more likely to wear their aligners consistently, participate actively in daily life, and carry themselves with the confidence that supports healthy social and emotional development.

Do orthodontists recommend Invisalign clear aligners?

Yes, Invisalign clear aligners are the #1 orthodontist recommended clear aligner treatment for teeth straightening, globally.26 Confidence in Invisalign clear aligners for early interceptive care is particularly high: in a global survey, 86% of orthodontists who use Invisalign treatment expressed satisfaction with eruption compensation features for mixed dentition patients,27 and 89% who used Invisalign clear aligners for Phase 1 treatment said they preferred continuing with Invisalign treatment for Phase 2, meaning starting early with Invisalign clear aligners sets the stage for a seamless full-treatment journey.28

What is Invisalign clear aligners treatment for younger children?

For parents of children between the ages of six and ten, early interceptive orthodontic care may help guide jaw development and create space for permanent teeth before more complex issues develop. Invisalign clear aligners include a dedicated option for growing patients, the first clear aligner product designed with features specifically for children in mixed dentition, including eruption compensation that adapts as baby teeth fall out and permanent teeth emerge. Over 95,700 younger patients have been treated globally with this early Invisalign clear aligners option, reflecting a strong worldwide track record.29 In a global study, all surveyed orthodontists recommended Invisalign treatment for growing children, reinforcing its clinical credibility for Phase 1 early interceptive care.

What is the Invisalign Palatal Expander and how can it help my child?

For children between ages six and ten, a narrow upper jaw is one of the most common and most consequential early orthodontic issues. A narrow palate can lead to crowded teeth, crossbites, mouth breathing, disrupted sleep, and a greater need for complex treatment later in life. The Invisalign system includes a dedicated palatal expander designed to gently widen the upper jaw during the window when a child's mid-palatal suture is still flexible and maximally responsive to guided expansion.

Unlike traditional metal palatal expanders, which require a parent to manually turn a metal screw inside their child's mouth every day, the Invisalign treatment palatal expander works through a series of 3D-printed appliances that gradually widen the arch without any key-turning or complicated at-home adjustments. In independent clinical surveys, 100% of participating orthodontists experienced in Invisalign treatment agreed that the palatal expander is comfortable for kids to wear — because there is no metal or screw to turn as with traditional expanders. The same group unanimously agreed that children treated with this approach had a positive treatment experience overall.

The proof behind clear aligner jaw expansion for growing kids is stronger than ever. A 2025 study tracked children (averaging around eight years old) who used the Invisalign palatal expansion system for about 18 months. The results were outstanding: kids achieved significant widening across the entire upper jaw, opening up crucial space by an average of about 4 mm. This targeted widening effectively reduced crowding by an average of 3.83 mm, giving incoming adult teeth the room they need.30 Another 2024 clinical trial confirmed that this clear aligner approach is just as effective at widening the smile and increasing mouth volume as traditional, fixed expanders.31

But unlike traditional metal expanders that are adhered glued to the teeth, the Invisalign palatal expander has a massive practical advantage: it’s completely removable. Children can simply pop it out to brush and floss normally. This eliminates the trapped food, plaque buildup, and cleaning frustrations that come with permanent metal hardware. Beyond keeping mouths cleaner, orthodontists note a major emotional perk too, surveyed doctors agree that this gentle, discreet early treatment helps protect a young child's self-esteem and emotional well-being.

As an added benefit, widening a narrow jaw can also pave the way for healthier breathing. Because the roof of the mouth makes up the floor of the nasal passage, gently widening the palate opens up the airway, which can reduce chronic mouth breathing and help children get more oxygen at night.

If your child is between the ages of six and ten and shows signs of a narrow jaw, a crossbite, crowded adult teeth, or chronic mouth breathing, it’s the perfect time to act. Ask your dentist or orthodontist if Invisalign palatal expansion is the right step for your child's early smile blueprint.

At what age can my child start Invisalign treatment?

Quick answer: Invisalign clear aligners treatment can begin as early as age six, while children still have a mix of baby and permanent teeth. Treatment designed for younger patients is specifically built for growing smiles. The American Association of Orthodontists recommends a first orthodontic evaluation by age seven,1 often the ideal time to identify issues and discuss early intervention options with your child's doctor.

Many parents assume orthodontic treatment must wait until all permanent teeth have emerged — but that is not always the case. The mixed dentition phase, when baby and permanent teeth coexist, is actually a critical window for guiding jaw development before bone growth is complete.

The Invisalign clear aligners system for younger patients was the first clear aligner product designed with features specifically for growing smiles.32 This purpose-built design allows orthodontists to address a wide range of developing issues — including crowding, spacing, and narrow arches — during the years when the jaw is most responsive to gentle, guided correction.

The global reach of this approach reflects widespread clinical trust: globally, over 95,700 younger patients have been treated with Invisalign clear aligners treatment designed specifically for younger patients.29 In North America alone, over 33,300 young patients have received this specialized Invisalign clear aligners treatment, with more than 31,300 in EMEA and over 24,300 in APAC.33

Since 2001, over 6,000,000 teen patients age 19 or younger have been treated with the Invisalign system.34 This decades-long track record spans an enormous range of cases, ages, and tooth types — giving families confidence that Invisalign clear aligners treatment is a proven, well-established choice for growing patients.

Your child's treating doctor will determine the right starting age based on their individual dental development. What matters most is scheduling that first evaluation, typically by age seven, so you and your doctor can make that decision at exactly the right moment.

Are Invisalign clear aligners safe? What about BPA and allergens?

Quick answer: Yes.

Safety and comfort are naturally top of mind when exploring orthodontic options for your child. The Invisalign system is engineered with both clinical effectiveness and a child's everyday well-being in mind, making it the most researched clear aligner system in the entire orthodontic industry.35 Backed by decades of peer-reviewed clinical science across global medical databases, it gives families and doctors total confidence in the treatment plan.

A big part of that confidence comes down to the materials used. Invisalign clear aligners are made from a premium, multi-layer material called SmartTrack, which is clinically proven to improve tooth movement.15 For younger patients, this smooth, flexible design is a game-changer—minimizing irritation inside the mouth and making daily wear completely hassle-free.

For parents managing sensitivities or allergies, the system’s fun accessories, like Stickables stickers, are completely non-toxic and non-irritating.36 They are entirely free from latex, BPA, food preservatives, and common food allergens—including nuts and shellfish.

Because every child’s smile is unique, parents with specific allergy concerns or medical questions should always consult their treating doctor before getting started. Your orthodontist is best positioned to customize the perfect, safest plan for your child's developing smile.

Ready to find an Invisalign treatment provider near me?

The earlier you act, the greater the advantage. If you have been searching for "Invisalign treatment for kids near me" or "Invisalign clear aligners for kids near me," the next step is simple: connect with a qualified local provider who can evaluate your child's smile in person.

During a consultation, your child's dentist or orthodontist will review their dental development, identify any issues that may benefit from early intervention, and walk you through whether Invisalign clear aligners treatment is the right fit. Many practices offer complimentary or low-cost initial consultations, and the earlier you schedule, the more treatment options may be available.

Here is what to expect at a first consultation:

A review of your child's current bite, spacing, and jaw alignment

A discussion of whether Phase 1 (early interceptive) treatment is recommended

An overview of the Invisalign clear aligners treatment process, timeline, and costs

Answers to any questions you have about aligners, compliance, or your child's specific needs

With thousands of providers trained in Invisalign treatment across the United States, finding expert care close to home has never been more accessible. Use the Invisalign treatment doctor locator at the official Invisalign treatment website to search for a certified provider near you and book your child's evaluation today.

Giving your child a healthy, confident smile is one of the best investments you can make, and it starts with a single conversation with a trusted local provider.

Results may vary. Consult your orthodontist or dentist to determine if Invisalign treatment is right for you.



Disclaimer: The information provided on this website is for educational and informational purposes only and does not constitute medical advice. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. You should consult your healthcare provider regarding any dental or medical condition and not disregard or delay seeking advice based on information found here. Individual experiences with treatments, such as Invisalign, may vary. Comparative statements are based on cited studies and are not intended to imply clinical superiority. Always seek professional advice for your specific needs.

Wonder if Invisalign treatment is right for you?

  1. American Association of Orthodontists. "Is Early Orthodontics Worth It? How Early Care Saves Money." https://aaoinfo.org/whats-trending/early-orthodontic-care-may-help-you-avoid-costly-treatments/. Accessed 04/29/26.
  2. Chen J, et al. "Prevalence of Malocclusion Traits in Primary Dentition, 2010–2024: A Systematic Review." Healthcare (MDPI). 2024;12(13):1321. https://www.mdpi.com/2227-9032/12/13/1321
  3. "Timing of Orthodontic Intervention for Pediatric Class II Malocclusion: A Systematic Review on Early vs. Late Treatment Outcomes." MDPI Children. 2024. https://pmc.ncbi.nlm.nih.gov/articles/PMC12651552/
  4. Banu A, et al. "The impact of malocclusion on the oral health related quality of life of 11–14-year-old children." BMC Pediatrics. 2022. https://pmc.ncbi.nlm.nih.gov/articles/PMC8842896/
  5. Barbosa TS, et al. "Impact of malocclusion on the quality of life of children aged 8 to 10 years." Dental Press Journal of Orthodontics. 2018. https://pmc.ncbi.nlm.nih.gov/articles/PMC6018448/
  6. Data on File at Align Technology, as of July 12 2017: *Based on a global claims survey by Actionable Research of Invisalign providers, respondents were asked the following question: In what percent of cases do patients require an emergency visit? (Global respondents N= 898)
  7. Buschang et al; Comparative time efficiency of aligner therapy and conventional edgewise braces. Angle Orthod 1 May 2014; 84 (3): 391–396. Borda et al; Outcome assessment of orthodontic clear aligner vs fixed appliance treatment in a teenage population with mild malocclusions. Angle Orthod 1 July 2020; 90 (4): 485–490.
  8. With weekly aligner changes, compared with two-week aligner wear based on treatment duration of first ClinCheck treatment plans.
  9. Complex cases include Class II, open bite, bicuspid extraction, and deep bite. Data on file at Align Technology, as of September 30, 2025.
  10. In a pain score of 1-9, 1 being extremely painful and 9 not at all painful, Invisalign teenager patients (age 13-18 n=106) rated pain score of 6.5 vs traditional metal braces teenager patients (age 13-18 n=141) rated pain score of 5.1. Data on file at Align Technology, as of December 28, 2022.
  11. In a survey of patients age 13–18 rating on a scale of 1–9, with 1 as “not at all comfortable” and 9 as “very comfortable”, traditional metal braces patients (n=141) rated 5.5, while Invisalign patients (n=106) rated comfort higher at 7.1. Data on file at Align Technology, December 28, 2022.
  12. Based on a survey in Dec 2020 to Mar 2021 of n=274 Invisalign Orthodontists who submitted 1+ teen cases past 12 months (November 2019–October 2020), who were asked how much they agree that Invisalign clear aligners offer a range of treatment options to fix a broad range of malocclusions. Agreement scale 1-4. Doctors were surveyed in NA, EMEA, APAC and LATAM. Data on file at Align Technology, as of April 26, 2021.
  13. Data on file at Align Technology as of June 29, 2018, based on n=40 from a multicenter NA IDE clinical study.
  14. Based on a survey of n=1340 parents of tweens and teens 11-16 who would be open to considering orthodontic treatment if recommended by their dentist or orthodontist, who were asked "Which of the following orthodontic treatments would you prefer for your tween or teenager age 11-16?" Examples of functional appliances are Twin Block and Herbst. Parents were surveyed from: USA, Canada, Mexico, Brazil, France, Italy, Spain, China, Japan, Australia, and New Zealand. Data on File at Align Technology, as of August 22, 2022.
  15. Data on file at Align Technology, and Wheeler et al, Effect of aligner material on orthodontic tooth movement. Journal of Aligner Orthodontics 2017 1(1): 21-27
  16. In a survey of patients age 13-18 rating on a scale of 1-9, with 1 as 'extremely painful' and 9 as 'not at all painful', traditional metal braces patients (n=141) rated 5.1, while Invisalign patients (n=106) rated pain lower at 6.5. On a scale of 1-9, with 1 as 'worst possible discomfort' and 9 as 'no discomfort', traditional metal braces patients (n=148) rated 5.1, while Invisalign patients (n=128) rated discomfort lower at 6.5. Data on file at Align Technology, for pain rating as of December 28, 2022, and for discomfort rating as of March 3, 2023.
  17. Based on significantly lower Plaque Index (PI), probing depth (PD), and Bleeding on Probing (BOP) of the upper right first molar and upper left central incisors at initial, 3,6, and 12 months as well as full month plaque score (FMPS) and full mouth bleeding score (FMBS) score at initial and 12 months and better higher compliance with oral hygiene on 50 teenager patients (age 10-18, (25 Invisalign treatment, 25 fixed appliances). Data on File at Align Technology, as of October 16, 2025. Abbate GM, et al. Periodontal health in teenagers treated with removable aligners and fixed orthodontic appliances. J Orofac Orthop 2015;76:240-50.
  18. "Clear Aligners vs Traditional Braces." Decisions in Dentistry. 2025. https://decisionsindentistry.com/article/clear-aligners-vs-traditional-braces/
  19. "Mampieri G, et al. "Effects of clear aligners treatment in growing patients: a systematic review." Frontiers in Oral Health. 2024;5:1512838. https://www.frontiersin.org/journals/oral-health/articles/10.3389/froh.2024.1512838/full
  20. "Assessment of the Effect of Rapid Maxillary Expansion on Nasal Respiratory Function and Obstructive Sleep Apnea Syndrome in Children: A Systematic Review." Journal of Clinical Medicine (MDPI). 2025;14(18):6565. https://www.mdpi.com/2077-0383/14/18/6565
  21. Kushida CA, et al. "Multicenter clinical trial for the treatment of obstructive sleep apnea with a non-permanent orthodontic intraoral device in children." European Journal of Pediatrics. 2025;184:424. https://doi.org/10.1007/s00431-025-06254-x
  22. U.S. surveyed teens who plan to start orthodontic treatment in the next year and are aware of the Invisalign brand. Data on File at Align Technology, as of March 6, 2017. Data on File: U.S. teen (13-17 y/o) teeth straightening intenders who are aware of Invisalign brand that indicated they ‘somewhat prefer Invisalign’ or ‘strongly prefer Invisalign’ when asked “Which of the following would you prefer for teeth straightening?” Invisalign vs Traditional Metal Braces (USA n=204).
  23. Based on the global survey in December 2020 to March 2021 in NA, EMEA and APAC regions included the following countries: USA, Canada, France, Italy, Spain, Brazil, Australia, China, Japan, 224 Invisalign orthodontists responded to the question: “Please indicate your agreement with the following statement: Phase 1 patients treated with Invisalign First aligners experience better quality of life (i.e. *including better ability to eat, oral hygiene, impact on their daily activities especially if playing sports/musical instruments) than those patients treated with functional appliances.” Agreement scale is 1-4 with 1 being “strongly disagree” and 4 being “strongly agree.”. Data on file at Align Technology, as of April 20, 2021
  24. "Comparison of acceptability of orthodontic appliances in children in mixed dentition treated with removable acrylic appliances and Invisalign First: a cross-sectional study." BMC Oral Health. 2024;24:1270. https://pmc.ncbi.nlm.nih.gov/articles/PMC11515626/
  25. American Association of Orthodontists. "The Link Between Orthodontic Treatment and Mental Health." https://www2.aaoinfo.org/the-link-between-orthodontic-treatment-and-mental-health/. Accessed 04/29/26.
  26. Based on a global survey of 1,786 doctors (dentists and orthodontists who use clear aligners) by IQVIA in NA, EMEA, LATAM, and APAC. Data on File at Align Technology, as of June 30, 2022.
  27. Based on the global survey in December 2020 to March 2021 in NA, EMEA and APAC regions which included the following countries (USA, Canada, France, Italy, Spain, Brazil, Australia, China, Japan), 224 Invisalign orthodontists responded to the question: “Please indicate your agreement with the following statement: “Thinking of Invisalign First patient cases you have treated in the past 12 months, please indicate your satisfaction with the eruption compensation feature for these Invisalign First Clear Aligners”. Satisfaction level is 1-4 with 1 being “very dissatisfied” and 4 being “very satisfied”. Data on file at Align Technology, as of April 20, 2021.
  28. Based on the global survey in December 2020 to March 2021 in NA, EMEA and APAC regions which included the following countries (USA, Canada, France, Italy, Spain, Brazil, Australia, China, Japan), 224 Invisalign orthodontists responded to the question: Please indicate your agreement with the following statement: I used Invisalign First for Phase 1 treatment, and therefore prefer using Invisalign aligners to treat Phase 2.” Agreement scale is 1-4 with 1 being “strongly disagree” and 4 being “strongly agree.” Data on file at Align Technology, as of April 20, 2021.
  29. Global case numbers are based on Invisalign First treatment shipments for patients 6-10 years old from July 1, 2018 to June 27, 2021 (varies by region). Data on file at Align Technology, as of June 27, 2021.
  30. "Skeletal and Dental-Alveolar Changes With Invisalign First Expansion System in the Mixed Dentition: A Retrospective Study." PMC. 2025. https://pmc.ncbi.nlm.nih.gov/articles/PMC12972221/
  31. "Efficacy of clear aligners vs rapid palatal expanders on palatal volume and surface area in mixed dentition patients: A randomized controlled trial." American Journal of Orthodontics and Dentofacial Orthopedics. 2024. https://www.ajodo.org/article/S0889-5406(24)00144-6/fulltext
  32. Data on File at Align Technology, as of April 26, 2018.
  33. NA case numbers are based on Invisalign First treatment shipments for patients 6-10 years old from July 1, 2018 to June 27, 2021 (varies by region). (includes US, Canada and Bermudas). *Data on file at Align Technology, as of June 27, 2021. EMEA case numbers are based on Invisalign First treatment shipments for patients 6-10 years old from July 1, 2018 to June 27, 2021. (includes countries where the product is commercially available). Data on file at Align Technology, as of June 27, 2021. APAC case numbers are based on Invisalign First treatment shipments for patients 6-10 years old from July 1, 2018 to June 27, 2021. (includes countries where the product is commercially available). *Data on file at Align Technology, as of June 27, 2021.
  34. Data on file at Align Technology, as of September 5, 2025.
  35. Based on a search conducted May 22, 2025 in leading scientific publication repositories PubMed, Cochrane Library, Chinese National Knowledge Infrastructure, and Wanfang Data. Data on File at Align Technology, as of May 22, 2025.
  36. Based on Align Technology testing and third-party Biocompatibility Risk Assessment Evaluation. Data on file at Align Technology, as of March 29, 2021.